兔抗PML多克隆抗体

Background:

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

Applications:

WB

Name of antibody:

PML

Immunogen:

Fusion protein of human PML

Full name:

promyelocytic leukemia

Synonyms：

MYL; RNF71; PP8675; TRIM19

SwissProt:

P29590

WB Predicted band size:

98 kDa

WB Positive control:

HeLa cells

WB Recommended dilution:

500-2000