兔抗GP1BA多克隆抗体

Background:

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy.

Applications:

ELISA, WB, IHC

Name of antibody:

GP1BA

Immunogen:

Fusion protein of human GP1BA

Full name:

glycoprotein Ib (platelet), alpha polypeptide

Synonyms：

BSS; GP1B; VWDP; CD42B; GPIbA; BDPLT1; BDPLT3; DBPLT3; CD42b-alpha

SwissProt:

P07359

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human liver cancer and human colon cancer

IHC Recommend dilution:

100-300

WB Predicted band size:

72 kDa

WB Positive control:

Mouse liver tissue

WB Recommended dilution:

500-2000