兔抗UNC13B多克隆抗体

Background:

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.

Applications:

ELISA, IHC

Name of antibody:

UNC13B

Immunogen:

Fusion protein of human UNC13B

Full name:

unc-13 homolog B

Synonyms:

UNC13; MUNC13; Unc13h2; munc13-2

SwissProt:

O14795

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human lung cancer

IHC Recommend dilution:

50-300