兔抗PCP4多克隆抗体

Background:

PCP-4 (Purkinje cell protein 4), also known as PEP-19, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer’s disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.

Applications:

ELISA, WB, IHC

Name of antibody:

PCP4

Immunogen:

Fusion protein of human PCP4

Full name:

purkinje cell protein 4

Synonyms：

PEP-19

SwissProt:

P48539

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human cervical cancer and human tonsil

IHC Recommend dilution:

100-300

WB Predicted band size:

7 kDa

WB Positive control:

Mouse brain tissue

WB Recommended dilution:

500-2000