兔抗NSD1多克隆抗体

Background:

This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.

Applications:

ELISA, IHC

Name of antibody:

NSD1

Immunogen:

Synthetic peptide of humanNSD1

Full name:

nuclear receptor binding SET domain protein 1

Synonyms：

STO; KMT3B; SOTOS; ARA267; SOTOS1

SwissProt:

Q96L73

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human prostate cancer

IHC Recommend dilution:

20-100