兔抗SAV1多克隆抗体

Background:

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor.

Applications:

ELISA, WB, IHC

Name of antibody:

SAV1

Immunogen:

Fusion protein of human SAV1

Full name:

salvador family WW domain containing protein 1

Synonyms:

SAV; WW45; WWP4

SwissProt:

Q9H4B6

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human brain and Human gastric cancer

IHC Recommend dilution:

100-300

WB Predicted band size:

45 kDa

WB Positive control:

HUVEC, PC-3 cell lysates

WB Recommended dilution:

500-2000