兔抗RUNX1(Ab-435) 多克隆抗体

Background:

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation.

Applications:

WB

Name of antibody:

RUNX1(Ab-435)

Immunogen:

Synthesized non-phosphopeptide derived from human AML1 around the phosphorylation site of serine 435 (S-N-S(p)-P-T).

Full name:

runt-related transcription factor 1

Synonyms：

AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; AML1-EVI-1

SwissProt:

Q01196

WB Predicted band size:

49 kDa

WB Positive control:

HepG2 cells treated with PMA (125ng/ml, 30mins) lysate

WB Recommended dilution:

500-3000