兔抗ROCK1多克隆抗体

Background:

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.

Applications:

ELISA, IHC

Name of antibody:

ROCK1

Immunogen:

Fusion protein of human ROCK1

Full name:

Rho-associated, coiled-coil containing protein kinase 1

Synonyms：

ROCK-I; P160ROCK

SwissProt:

Q13464

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human breast cancer and human gastric cancer

IHC Recommend dilution:

25-100