兔抗RNF126多克隆抗体

Background:

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. RNF126 interacts with p21 and RNF126 over-expression increased p21 protein ubiquitination in an E3 ligase activity-dependent manner. RNF126 knockdown induced loss of cell viability in MDA-MB-231 and PC-3 can be partially rescued by depletion of p21. RNF126 stable knockdown in PC3 inhibited tumor growth in SCID mice.

Applications:

ELISA, WB, IHC

Name of antibody:

RNF126

Immunogen:

Synthetic peptide of human RNF126

Full name:

Ring finger protein 126

SwissProt:

Q9BV68

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human thyroid cancer and Human brain

IHC Recommend dilution:

25-100

WB Predicted band size:

38 kDa

WB Positive control:

Jurkat and K562 cells

WB Recommended dilution:

500-2000