兔抗RNF111多克隆抗体

Background:

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Applications:

ELISA, WB, IHC

Name of antibody:

RNF111

Immunogen:

Fusion protein of human RNF111

Full name:

ring finger protein 111

Synonyms:

ARK; hRNF111

SwissProt:

Q6ZNA4

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human gastric cancer

IHC Recommend dilution:

50-300

WB Predicted band size:

109 kDa

WB Positive control:

TM4 cell lysate

WB Recommended dilution:

200-1000