购物车
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021-54845833/15800441009
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Background: |
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
FLNA |
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Immunogen: |
Fusion protein of human FLNA |
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Full name: |
filamin A, alpha |
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Synonyms： |
FLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280 |
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SwissProt: |
P21333 |
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ELISA Recommended dilution: |
2000-10000 |
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IHC positive control: |
Human colon cancer and Human brain |
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IHC Recommend dilution: |
50-200 |
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WB Predicted band size: |
281 kDa |
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WB Positive control: |
PC3, NIH/3T3 and HUVEB cells |
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WB Recommended dilution: |
1000-5000 |
