Background: |
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris. |
Applications: |
ELISA, IHC |
Name of antibody: |
FLG |
Immunogen: |
Synthetic peptide of human FLG |
Full name: |
filaggrin |
Synonyms: |
ATOD2 |
SwissProt: |
P20930 |
ELISA Recommended dilution: |
1000-2000 |
IHC positive control: |
Human cervical cancer and Human liver cancer |
IHC Recommend dilution: |
25-100 |