兔抗FBL多克隆抗体

Background:

Fibrillarin is a 2'-O-methyltransferase located in fibrillar regions and Cajal bodies of the nucleolus, where RNA transcription and pre-RNA processing take place. Fibrillarin associates with several other structual proteins as well as box C/D snoRNA to form a complex that functions in pre-rRNA processing, pre-rRNA methylation and ribosome assembly. This complex catalyzes site-specific 2'-O-ribose methylation of targeted nucleotides within the rRNA sequence. The sequence, structure and function of fibrillarin are highly conserved and fibrillarin gene expression is essential for early embryonic development.

Applications:

WB

Name of antibody:

FBL

Immunogen:

Fusion protein of human FBL

Full name:

fibrillarin

Synonyms：

FBL; FIB; FLRN; RNU3IP1

SwissProt:

P22087

WB Predicted band size:

34 kDa

WB Positive control:

Hela, A375, U20S, COS1, COS7 and PC12 cells, brain and testis tissue

WB Recommended dilution:

500-2000