Background: |
Human homolog is a cofactor for factor IXa; it involved in blood coagulation. Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. Interacts with VWF. VWF binding is essential for the stabilization of F8 in circulation. Secreted protein; extracellular space. Domain F5/8 type C 2 is responsible for phospholipid-binding and essential for factor VIII activity. Defects in F8 are the cause of hemophilia A (HEMA). Belongs to the multicopper oxidase family. |
Applications: |
IHC, IF |
Name of antibody: |
F8 |
Immunogen: |
KLH conjugated synthetic peptide derived from rat factor VIII |
Full name: |
coagulation factor VIII, procoagulant component |
SwissProt: |
P00451 |
ELISA Recommended dilution: |
500-1000 |
IF Recommended dilution: |
100-500 |