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  • VHL抗原(重组蛋白)

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    • 品牌 : 通蔚生物
    • 目录号 : TW20111
    • 应用 : 仅供科研使用
    • 保存条件 : 低温保存
    • 货期 : 现货
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中文名称: VHL抗原(重组蛋白)

英文名称: VHL Antigen (Recombinant Protein)

别     名:  RCA1; VHL1; pVHL; HRCA1

储     存:  冷冻(-20℃)

相关类别: 抗原

概     述

Full length fusion protein

技术规格

Full name:

von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

Synonyms:

RCA1; VHL1; pVHL; HRCA1

Swissprot:

P40337

Gene Accession:

BC058831

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.