购物车
帮助
021-54845833/15800441009
中文名称： 兔抗RELA (Phospho-Ser276) 多克隆抗体
英文名称： Anti-RELA (Phospho-Ser276) rabbit polyclonal antibody
别 名： p65; NFKB3
相关类别： 一抗
储 存： 冷冻（-20℃） 避光
宿 主： Rabbit
抗 原： RELA (Phospho-Ser276)
反应种属： Human, Mouse, Rat
标 记 物： Unconjugate
克隆类型： rabbit polyclonal
技术规格
|
Background: |
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. |
|
Applications: |
WB, IHC, IF |
|
Name of antibody: |
RELA (Phospho-Ser276) |
|
Immunogen: |
Synthetic peptide of human RELA (Phospho-Ser276) |
|
Full name: |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) (Phospho-Ser276) |
|
Synonyms： |
p65; NFKB3 |
|
SwissProt: |
Q04206 |
|
IHC positive control: |
Human breast carcinoma |
|
IHC Recommend dilution: |
50-100 |
|
WB Predicted band size: |
65 kDa |
|
WB Positive control: |
Hela cells |
|
WB Recommended dilution: |
500-1000 |
|
IF Positive control: |
Hela cells |
|
IF Recommended dilution |
100-200 |
