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    • 品牌 : 通蔚生物
    • 目录号 : TW19932
    • 应用 : 仅供科研使用
    • 保存条件 : 低温保存
    • 货期 : 现货
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中文名称:  兔抗ERN2多克隆抗体 

英文名称: Anti-ERN2 rabbit polyclonal antibody

别      名: IRE1b; IRE1-BETA

相关类别: 一抗

储      存: 冷冻(-20℃)

宿      主: Rabbit

抗      原: ERN2

反应种属: Human

标  记 物: Unconjugate

克隆类型: rabbit polyclonal

技术规格

Background:

The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.

Applications:

ELISA, IHC

Name of antibody:

ERN2

Immunogen:

Synthetic peptide of human ERN2

Full name:

endoplasmic reticulum to nucleus signaling 2

Synonyms:

IRE1b; IRE1-BETA

SwissProt:

Q76MJ5

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and Human gastric cancer

IHC Recommend dilution:

50-200