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中文名称：兔抗RBM4多克隆抗体
英文名称： Anti-RBM4 rabbit polyclonal antibody
别 名： RNA binding motif protein 4; LARK; RBM4A; ZCRB3A; ZCCHC21
相关类别： 一抗
储 存： 冷冻（-20℃）
宿 主： Rabbit
抗 原： RBM4
反应种属： Human, Mouse
标记物： Unconjugate
克隆类型： rabbit polyclonal
技术规格
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Background: |
RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. |
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Applications: |
ELISA, WB |
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Name of antibody: |
RBM4 |
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Immunogen: |
Fusion protein of human RBM4 |
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Full name: |
RNA binding motif protein 4 |
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Synonyms: |
LARK; RBM4A; ZCRB3A; ZCCHC21 |
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SwissProt: |
Q9BWF3 |
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ELISA Recommended dilution: |
5000-10000 |
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WB Predicted band size: |
40 kDa |
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WB Positive control: |
K562 and HepG2 cell lysates |
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WB Recommended dilution: |
500-2000 |
