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相关类别： 抗原
概 述
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Full name: |
ribosomal modification protein rimK-like family member B |
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Synonyms: |
NAAGS; FAM80B; NAAGS-I |
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Swissprot: |
Q9ULI2 |
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Gene Accession: |
BC033793 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
RIMKLB (ribosomal modification protein rimK-like family member B), also known as NAAGS (N-acetyl-aspartyl-glutamate synthetase B), beta-citryl-glutamate synthase B or FAM80B, is a 386 amino acid cytoplasmic protein that belongs to the rimK family. Acting as the catalyst in the synthesis of beta-citryl-glutamate and N-acetyl-aspartyl-glutamate, RIMKLB contains one ATP-grasp domain and exists as two alternatively spliced isoforms. The gene encoding RIMKLB maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders. |
