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别 名： MWFE; ZNF183; CI-MWFE
相关类别： 抗原
概 述
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Full name: |
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa |
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Synonyms: |
MWFE; ZNF183; CI-MWFE |
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Swissprot: |
O15239 |
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Gene Accession: |
BC000266 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. |
