Background: |
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. |
Applications: |
WB, IHC |
Name of antibody: |
EIF4EBP1(Ab-69) |
Immunogen: |
Synthesized non-phosphopeptide derived from human 4E-BP1 around the phosphorylation site of threonine 70 (A-K-T-P-P). |
Full name: |
eukaryotic translation initiation factor 4E binding protein 1 |
Synonyms: |
BP-1; 4EBP1; 4E-BP1; PHAS-I |
SwissProt: |
Q13541 |
IHC positive control: |
Human colon carcinoma tissue |
IHC Recommend dilution: |
50-100 |
WB Predicted band size: |
13 kDa |
WB Positive control: |
COS7 cells treated with EGF (200ng/ml, 30mins) lysate |
WB Recommended dilution: |
500-3000 |