Background: |
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity). |
Applications: |
ELISA, IHC |
Name of antibody: |
EIF4E2 |
Immunogen: |
Fusion protein of human EIF4E2 |
Full name: |
eukaryotic translation initiation factor 4E family member 2 |
Synonyms: |
4EHP; IF4e; 4E-LP; h4EHP; EIF4EL3 |
SwissProt: |
O60573 |
ELISA Recommended dilution: |
5000-10000 |
IHC positive control: |
Human liver cancer |
IHC Recommend dilution: |
50-200 |