兔抗MMP8多克隆抗体

Background:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Applications:

ELISA, WB, IHC

Name of antibody:

MMP8

Immunogen:

Synthetic peptide of human MMP8

Full name:

matrix metallopeptidase 8 (neutrophil collagenase)

Synonyms：

HNC, CLG1, MMP-8, PMNL-CL

SwissProt:

P22894

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human colon cancer and Human ovarian cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

53 kDa

WB Positive control:

231 cells

WB Recommended dilution:

500-2000