兔抗EDARADD多克隆抗体

Background:

This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Applications:

ELISA, IHC

Name of antibody:

EDARADD

Immunogen:

Full length fusion protein

Full name:

EDAR-associated death domain

Synonyms:

ED3; EDA3; ECTD11A; ECTD11B

SwissProt:

Q8WWZ3

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil

IHC Recommend dilution:

35-200