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021-54845833/15800441009
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Background: |
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
DUSP10 |
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Immunogen: |
Fusion protein of human DUSP10 |
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Full name: |
dual specificity phosphatase 10 |
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Synonyms： |
MKP5; MKP-5 |
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SwissProt: |
Q9Y6W6 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human brain and human thyroid cancer |
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IHC Recommend dilution: |
25-100 |
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WB Predicted band size: |
53 kDa |
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WB Positive control: |
Mouse brain tissue |
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WB Recommended dilution: |
200-1000 |
