兔抗DUSP6多克隆抗体

Background:

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

DUSP6

Immunogen:

Fusion protein of human DUSP6

Full name:

dual specificity phosphatase 6

Synonyms：

MKP3, PYST1

SwissProt:

Q16828

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human ovarian cancer and human tonsil

IHC Recommend dilution:

25-100

WB Predicted band size:

27 kDa

WB Positive control:

Jurkat cells and human fetal kidney tissue

WB Recommended dilution:

500-2000