兔抗DMTN多克隆抗体

Background:

The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms.

Applications:

ELISA, WB, IHC

Name of antibody:

DMTN

Immunogen:

Synthetic peptide of human DMTN

Full name:

dematin actin binding protein

Synonyms:

DMT; EPB49

SwissProt:

Q08495

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human gastric cancer;

IHC Recommend dilution:

20-100

WB Predicted band size:

46 kDa

WB Positive control:

293T cell, Human cerebrum tissue and Mouse brain tissue lysates

WB Recommended dilution:

500-2000