兔抗DMAP1多克隆抗体

Background:

This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.

Applications:

ELISA, WB, IHC

Name of antibody:

DMAP1

Immunogen:

Synthetic peptide of human DMAP1

Full name:

DNA methyltransferase 1 associated protein 1

Synonyms:

EAF2; SWC4; MEAF2; DNMAP1; DNMTAP1

SwissProt:

Q9NPF5

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human gastric cancer;Human thyroid cancer

IHC Recommend dilution:

20-100

WB Predicted band size:

53 kDa

WB Positive control:

231 and Hela cell lysates

WB Recommended dilution:

200-1000