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021-54845833/15800441009
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Background: |
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein. Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
DIABLO |
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Immunogen: |
Fusion protein of human DIABLO |
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Full name: |
Diablo, IAP-binding mitochondrial protein |
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Synonyms： |
SMAC; SMAC3; DFNA64; DIABLO-S |
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SwissProt: |
Q9NR28 |
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ELISA Recommended dilution: |
2000-10000 |
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IHC positive control: |
Human colon cancer and Human liver cancer |
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IHC Recommend dilution: |
50-200 |
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WB Predicted band size: |
27 kDa |
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WB Positive control: |
Lncap, SKOV3, MCF7 and 293T cells |
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WB Recommended dilution: |
1000-5000 |
