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中文名称：TPMT 抗原（重组蛋白）
英文名称： TPMT Antigen (Recombinant Protein)
别 名： thiopurine S-methyltransferase; TPMTD
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 1-245 amino acids of human TPMT |
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Full name: |
thiopurine S-methyltransferase |
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Synonyms: |
TPMTD |
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Swissprot: |
P51580 |
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Gene Accession: |
BC005339 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. |
