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  • NGEF 抗原(重组蛋白)

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    • 品牌 : 通蔚生物
    • 目录号 : TW18306
    • 应用 : 仅供科研使用
    • 保存条件 : 低温保存
    • 货期 : 现货
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中文名称NGEF 抗原(重组蛋白)

英文名称 NGEF Antigen (Recombinant Protein)

别      名 neuronal guanine nucleotide exchange factor; EPHEXIN; ARHGEF27

储      存: 冷冻(-20℃)

相关类别: 抗原

概      述:

Fusion protein corresponding to a region derived from 511-710 amino acids of human NGEF


技术规格

Full name:

neuronal guanine nucleotide exchange factor

Synonyms:

EPHEXIN; ARHGEF27

Swissprot:

Q8N5V2

Gene Accession:

BC031573

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).