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中文名称：MECP2 抗原（重组蛋白）
英文名称： MECP2 Antigen (Recombinant Protein)
别 名： methyl CpG binding protein 2; RS; RTS; RTT; PPMX; MRX16; MRX79; MRXSL; AUTSX3; MRXS13
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述
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Fusion protein corresponding to N terminal 162 amino acids of human MECP2 |
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Full name: |
methyl CpG binding protein 2 |
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Synonyms: |
RS; RTS; RTT; PPMX; MRX16; MRX79; MRXSL; AUTSX3; MRXS13 |
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Swissprot: |
P51608 |
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Gene Accession: |
BC011612 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. |
