兔抗DFFB多克隆抗体

Background:

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of these variants has not been determined.

Applications:

ELISA, IHC

Name of antibody:

DFFB

Immunogen:

Synthetic peptide of human DFFB

Full name:

DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)

Synonyms：

CAD; CPAN; DFF2; DFF40; DFF-40

SwissProt:

O76075

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human esophagus cancer

IHC Recommend dilution:

25-100