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    PHF21A抗原（重组蛋白）

    PHF21A抗原（重组蛋白）

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    • 品牌 : 通蔚生物
    • 目录号 : TW18077
    • 应用 : 仅供科研使用
    • 保存条件 : 低温保存
    • 货期 : 现货
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中文名称：  PHF21A抗原（重组蛋白）

英文名称： PHF21A Antigen (Recombinant Protein)

别        名： PHD finger protein 21A; BHC80; BM-006

相关类别： 抗原

储        存： 冷冻（-20℃）

概述

Fusion protein corresponding to a region derived from 481-680 amino acids of human PHF21A

技术规格

Full name:

PHD finger protein 21A

Synonyms:

BHC80; BM-006

Swissprot:

Q96BD5

Gene Accession:

BC015714

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. PHF21A (PHD finger protein 21A), also known as BRAF35-HDAC complex protein BHC80, is a 680 amino acid nuclear protein that contains one PHD-type zinc finger and one A.T hook DNA-binding domain, suggesting involvement in transcriptional regulation events. PHF21A is a component of the BHC complex, which is responsible for repressing transcription of neuron-specific genes in non-neuronal cells. The BHC complex acts as a chromatin modifier that deacetylates and demethylates specific sites on histones. PHF21A may act as a scaffold within the BHC complex. Predominantly expressed in brain, three isoforms of PHF21A exist as a result of alternative splicing events.