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中文名称： IMPDH2 抗原（重组蛋白）
英文名称： IMPDH2 Antigen (Recombinant Protein)
储 存： 冷冻（-20℃）
别 名： IMP (inosine 5'-monophosphate) dehydrogenase 2; IMPD2; IMPDH-II
相关类别： 抗原
概述
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Fusion protein corresponding to a region derived from 114-237 amino acids of human IMPDH2 |
技术规格
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Full name: |
IMP (inosine 5'-monophosphate) dehydrogenase 2 |
|
Synonyms: |
IMPD2; IMPDH-II |
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Swissprot: |
P12268 |
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Gene Accession: |
BC006124 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. |
