Background: |
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. |
Applications: |
ELISA, WB |
Name of antibody: |
DDC |
Immunogen: |
Synthetic peptide of human DDC |
Full name: |
dopa decarboxylase |
Synonyms: |
AADC |
SwissProt: |
P20711 |
ELISA Recommended dilution: |
5000-10000 |
WB Predicted band size: |
54 kDa |
WB Positive control: |
Human left kidney tissue and Human fetal liver tissue lysates |
WB Recommended dilution: |
1000-5000 |