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    NELFA抗原（重组蛋白）

    NELFA抗原（重组蛋白）

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    • 品牌 : 通蔚生物
    • 目录号 : TW17744
    • 应用 : 仅供科研使用
    • 保存条件 : 低温保存
    • 货期 : 现货
    • 商品库存：40
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中文名称： NELFA抗原（重组蛋白）

英文名称： NELFA Antigen (Recombinant Protein)

别        名： negative elongation factor complex member A; WHSC2; NELF-A; P/OKcl.15
相关类别： 抗原

储    存： 冷冻（-20℃） 
概述
Fusion protein corresponding to a region derived from 329-528 amino acids of human NELFA

技术规格

Full name:

negative elongation factor complex member A

Synonyms:

WHSC2; NELF-A; P/OKcl.15

Swissprot:

Q9H3P2

Gene Accession:

BC002764

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.