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Fusion protein corresponding to a region derived from 401-604 amino acids of human PTGS2 |
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Full name: |
prostaglandin-endoperoxide synthase 2 |
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Synonyms: |
COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS |
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Swissprot: |
P35354 |
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Gene Accession: |
BC013734 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. |
