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中文名称：FLT3抗原（重组蛋白）
英文名称： FLT3 Antigen (Recombinant Protein)
别 名： FLK2; STK1; CD135; FLK-2
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
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Fusion protein corresponding to a region derived from 610-943 amino acids of human FLT3 |
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Full name: |
fms related tyrosine kinase 3 |
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Synonyms: |
FLK2; STK1; CD135; FLK-2 |
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Swissprot: |
P36888 |
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Gene Accession: |
BC126350 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. |
