Full name: |
suppression of tumorigenicity 14 (colon carcinoma) |
Synonyms: |
HAI; MTSP1; SNC19; MT-SP1; PRSS14; TADG15; TMPRSS14 |
Swissprot: |
Q9Y5Y6 |
Gene Accession: |
BC030532 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. |