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  • ENG抗原(重组蛋白)

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    • 品牌 : 通蔚生物
    • 目录号 : TW17204
    • 应用 : 仅供科研使用
    • 保存条件 : 低温保存
    • 货期 : 现货
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中文名称:  ENG抗原(重组蛋白)

英文名称: ENG Antigen (Recombinant Protein)

别      名: END; HHT1; ORW1

储      存: 冷冻(-20℃)

相关类别: 抗原

概  述:

Fusion protein corresponding to a region derived from 409-658 amino acids of human ENG


技术规格: 

Full name:

endoglin

Synonyms:

END; HHT1; ORW1

Swissprot:

P17813

Gene Accession:

BC014271

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.