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021-54845833/15800441009
中文名称： DYNLL1抗原（重组蛋白）
英文名称： DYNLL1 Antigen (Recombinant Protein)
别 名： LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
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Fusion protein corresponding to a region derived from 1-89 amino acids of human DYNLL1 |
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Full name: |
dynein, light chain, LC8-type 1 |
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Synonyms: |
LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1 |
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Swissprot: |
P63167 |
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Gene Accession: |
NP_003737 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. |
