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  • PTCH1抗原(重组蛋白)

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    • 品牌 : 通蔚生物
    • 目录号 : TW17113
    • 应用 : 仅供科研使用
    • 保存条件 : 低温保存
    • 货期 : 现货
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中文名称: PTCH1抗原(重组蛋白)

英文名称: PTCH1 Antigen (Recombinant Protein)

别       名: PTC, BCNS, HPE7, PTC1, PTCH, NBCCS, PTCH11

储       存 冷冻(-20℃)

相关类别: 抗原

概述

Fusion protein corresponding to a region derived from 1-183 amino acids of human PTCH1

技术规格

Full name:

patched 1

Synonyms:

PTC, BCNS, HPE7, PTC1, PTCH, NBCCS, PTCH11

Swissprot:

Q13635

Gene Accession:

BC043542

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.