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中文名称： DLD抗原（重组蛋白）
英文名称： DLD Antigen (Recombinant Protein)
别 名： E3; LAD; DLDD; DLDH; GCSL; PHE3
相关类别： 抗原
概 述：
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Fusion protein corresponding to C terminal 250 amino acids of human DLD |
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Full name: |
dihydrolipoamide dehydrogenase |
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Synonyms: |
E3; LAD; DLDD; DLDH; GCSL; PHE3 |
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Swissprot: |
P09622 |
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Gene Accession: |
BC018696 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. Alternative splicing results in multiple transcript variants. |
