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    PLAU抗原（重组蛋白）

    PLAU抗原（重组蛋白）

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    • 品牌 : 通蔚生物
    • 目录号 : TW17054
    • 应用 : 仅供科研使用
    • 保存条件 : 低温保存
    • 货期 : 现货
    • 商品库存：40
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中文名称： PLAU抗原（重组蛋白）

英文名称： PLAU Antigen (Recombinant Protein)

别       名： ATF; QPD; UPA; URK; u-PA; BDPLT5

储       存： 冷冻（-20℃）

相关类别： 抗原

概述

Fusion protein corresponding to a region derived from 179-417 amino acids of human PLAU

技术规格

Full name:

plasminogen activator, urokinase

Synonyms:

ATF; QPD; UPA; URK; u-PA; BDPLT5

Swissprot:

P00749

Gene Accession:

BC013575

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.