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    PGC抗原（重组蛋白）

    PGC抗原（重组蛋白）

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    • 品牌 : 通蔚生物
    • 目录号 : TW17039
    • 应用 : 仅供科研使用
    • 保存条件 : 低温保存
    • 货期 : 现货
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中文名称： PGC抗原（重组蛋白）

英文名称： PGC Antigen (Recombinant Protein)

别      名： PEPC, PGII

储      存： 冷冻（-20℃）

相关类别： 抗原

概述

Fusion protein corresponding to a region derived from 1-97 amino acids of human PGC

技术规格

Full name:

progastricsin (pepsinogen C)

Synonyms:

PEPC, PGII

Swissprot:

P20142

Gene Accession:

BC042578

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.