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中文名称： CYP17A1抗原（重组蛋白）
英文名称： CYP17A1 Antigen (Recombinant Protein)
别 名： CPT7; CYP17; S17AH; P450C17
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
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Fusion protein corresponding to a region derived from C terminal 250 amino acids of human CYP17A1 |
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Full name: |
cytochrome P450, family 17, subfamily A, polypeptide 1 |
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Synonyms: |
CPT7; CYP17; S17AH; P450C17 |
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Swissprot: |
P05093 |
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Gene Accession: |
BC063388 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. |
