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中文名称： CYP2C9抗原（重组蛋白）
英文名称： CYP2C9 Antigen (Recombinant Protein)
别 名： CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 1-162 amino acids of human CYP2C9 |
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Full name: |
cytochrome P450, family 2, subfamily C, polypeptide 9 |
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Synonyms: |
CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9 |
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Swissprot: |
P11712 |
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Gene Accession: |
BC020754 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. |
