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中文名称：CBS抗原（重组蛋白）
英文名称： CBS Antigen (Recombinant Protein)
别 名： HIP4
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to C terminal 300 amino acids of human CBS |
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Full name: |
cystathionine-beta-synthase |
|
Synonyms: |
HIP4 |
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Swissprot: |
P35520 |
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Gene Accession: |
BC010242 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene. |
