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    MICA抗原（重组蛋白）

    MICA抗原（重组蛋白）

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    • 品牌 : 通蔚生物
    • 目录号 : TW16842
    • 应用 : 仅供科研使用
    • 保存条件 : 低温保存
    • 货期 : 现货
    • 商品库存：40
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中文名称： MICA抗原（重组蛋白）

英文名称： MICA Antigen (Recombinant Protein)

别      名： MIC-A; PERB11.1

储     存： 冷冻（-20℃）

相关类别： 抗原

概述
Fusion protein corresponding to a region derived from 24-307 amino acids of human MICA

技术规格

Full name:

MHC class I polypeptide-related sequence A

Synonyms:

MIC-A; PERB11.1

Swissprot:

Q29983

Gene Accession:

BC016929

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.